CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
One concept to reduce the adverse effects of opioids is the use of very small doses of opioid antagonists. 25 – 28 The rationale is that agents such as naloxone (Narcan) have a biphasic effect whereby very low doses reduce the incidence of opioid adverse effects and may augment the analgesic effect. 25 , 28 Much of the data are limited to the inpatient setting with intravenous administration of the opioid antagonist. 25 – 27 Concomitant administration of intravenous naloxone with morphine infusions has been studied, but the results have been mixed. 25 – 27 More research is needed before this treatment is implemented as part of routine practice.