A thermogenic is a broad term for any supplement that the manufacturer claims will cause thermogenesis , resulting in increased body temperature, increased metabolic rate, and consequently an increased rate in the burning of body fat and weight loss. Until 2004 almost every product found in this supplement category comprised the " ECA stack ": ephedrine , caffeine and aspirin . However, on February 6, 2004 the Food and Drug Administration (FDA) banned the sale of ephedra and its alkaloid , ephedrine, for use in weight loss formulas. Several manufacturers replaced the ephedra component of the "ECA" stack with bitter orange or citrus aurantium (containing synephrine ) instead of the ephedrine.
It must be noted possible side-effects such as Gynecomastia , water retention, high blood pressure and high cholesterol are all a possibility with this cycle as both Testosterone and Dianabol aromatize and cause a buildup in estrogen . If you’re nipples begin to get sore while on cycle you might try supplementing with 10mg of Nolvadex per day. If this does not work you are going to need an Aromatase Inhibitor such as Arimidex or Letrozole ; every other day of either should suffice. Further, if you keep your diet clean you will largely protect from water retention; some will occur if you are really trying to bulk but limit your excess calories only to what you absolutely need and avoid overeating carbohydrates. Further, keeping your diet clean is also good for your blood pressure and cholesterol; moreover, consuming plenty of Omega-3 Fatty Acids can greatly serve you here.
After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .