After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .
As alluded to above, one very important thing to acknowledge when using AAS (whether taking one hormone, stacking or cycling) is the risk of harmful side effects. Within a steroid cycle, the users will often stack other non-anabolic hormones into their program to maximize specific cycle objectives for example: the addition of drugs like Clenbuterol and/or Cytomel /T3 augment cutting/definition cycles; others called aromatase inhibitors (estrogen reducing drugs) like Letrozole . Letro and Anastrozole Arimidex are often included to inhibit the conversion of excess testosterone to negatively cycle impacting estrogen and; incorporating post-cycle therapy (PCT) drugs such as the synthetic estrogens Tamoxifen . Nolvadex , or Clomiphene Citrate . Clomid (which act as anti-estrogens in the male body), can be used alone, together, or in conjunction with those like Mesterolone . Proviron and Human Chorionic Gonadotropin ( HCG ) during PCT to bridge the gap between the end of a steroid cycle (synthetic testosterone usage) and the restoration of the bodys natural testosterone production. These drugs too must be researched, and controlled in similar fashion to AAS. Thus, steroid cycles can be as simple or complex as the users individualized goals, cycle histories and levels of understanding. Below are three samples of AAS stacked cycles of varying complexity along with a beginning PCT sample, and an explanation of goal intention & rationale for the selected compounds, dosages & durations. These illustrations and commentaries will provide a better understanding of what stacking and cycling are along with the many nuances they require.
As we discussed above, Dianabol carries a strong aromatizing nature, and is a C17-aa anabolic steroid; as such, its side-effects will revolve around these factors. As an aromatizing steroid, this means there can be a testosterone to estrogen conversion, and if estrogen levels go to high it can lead to some complications. When estrogen levels increase, the hormone can attach to the receptors and cause gynecomastia (male-breast enlargement) and it can also promote excess water retention and high blood pressure; Dbol is notorious for promoting high blood pressure. Needless to say, if you already suffer from high blood pressure you should not touch this steroid, but if it's healthy you'll need to ensure it stays this way. For this reason, in-order to combat and avoid these estrogenic side-effects of Dbol, the use of an Aromatase Inhibitor (AI) is often advised. It shouldn't be too hard to see how this can help; after all, an AI inhibits aromatase, but it goes a step further by reducing the body's total estrogen levels. Of course, and this cannot be overstressed, you must keep your doses at a responsible level; most will need at least 20mg per day for any anabolic promotion, with a maximum dosing of 50mg per day. It should be noted; if you've never used this steroid before, you should not start with a high end dose; start low and see how you respond.