Estradiol's efficacy seems to vary widely with the person and the particular vehicle: I was on transdermal patches for two years ( , 2 patches changed twice weekly – considered a "high" dose of 17-beta estradiol), and my levels mostly stayed around 100 pg/mL, and I needed 100mg spironolactone daily to keep my testosterone down. When I switched to injections of Estradiol Valerate, as I was "titrating up" my testosterone was unmeasurably low at the same E2 level my patches were delivering. (I had decided to drop spiro at the same time due to it's side effects: for me it seemed to be fogging my brain and inducing suicidal ideation.) Increasing the dosage had the effect of adding a cup-size to my breasts after about two months of injections, after two years of HRT, at age 53 and with b-cup breasts already. This story is not unusual in the community, and it led me to try this form of HRT.
The prime advantage of this product is the fact that Testosterone Cypionate can be injected once per week and it gives some very good gains in strength and size. I would bet that many careers testonon in bodybuilding and athletics were built with the long term use of this drug. I’ve used it at doses of 250-2,000 mg per week, and found that the best gains versus side effects are probably had somewhere below the 750 mg/week mark. Of course this is far below what many competitors in the upper ranks of bodybuilding use, but for the average (recreational) bodybuilder or athlete, the side effects above this dose do not constitute an acceptable trade off for the gains.
The side effects of Dianabol vary greatly depending on your individual tolerance, your dosage, and your stack choices. For the most part, though, healthy and fit men tend to tolerate Dbol quite well. The two most common Dianabol side effects for men come from its high estrogen conversion rate. Almost all users experience some bloating and discomfort, and some men develop gynecomastia, or female breast tissue. To avoid these, be certain to incorporate an aromatase inhibitor into your Dianabol cycle. What’s more, bloating increases blood pressure due to the extra fluid in the body. To combat this, you can find many diuretics over the counter.