In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed.  In patients with dysthymia , unipolar , and bipolar depression significant improvement was observed.  In this series of studies, mesterolone lead to a significant decrease in luteinizing hormone and testosterone levels.  In another study, 100 mg mesterolone cipionate was administered twice monthly.  With regards to plasma testosterone levels, there was no difference between the treated versus untreated group, and baseline luteinizing hormone levels were minimally affected. 
Laureate Pharma . and Southern Research Institute have initiated a strategic collaboration agreement related to developing and manufacturing drug-delivery products using Southern Research’s proprietary microencapsulation process technologies. Under the agreement, Laureate Pharma and Southern Research will collaborate to provide pharmaceutical clients with full microencapsulation services that range from development through commercial scale manufacturing. Terms of Read more about Laureate And Southern Research Institute Announce Collaboration […]
The androgenic effects of tibolone have been postulated to be involved in the reduced breast cell proliferation , reduced breast cancer risk, improvement in sexual function , less unfavorable changes in hemostatic parameters relative to estrogen–progestogen combinations, and changes in liver protein synthesis (., 30% reductions in HDL cholesterol levels, 20% reduction in triglyceride levels, and 50% reduction in SHBG levels) observed with tibolone.   They are also responsible for the androgenic side effects of tibolone in some women such as acne and increased hair growth .