Noretynodrel was first synthesized by Frank B. Colton of G. D. Searle & Company in 1952, and this was preceded by the synthesis of norethisterone by Luis E. Miramontes and Carl Djerassi of Syntex in 1951.  In 1957, both noretynodrel and norethisterone, in combination with mestranol , were approved in the United States for the treatment of menstrual disorders .  In 1960, noretynodrel, in combination with mestranol (as Enovid ), was introduced in the United States as the first oral contraceptive, and the combination of norethisterone and mestranol followed in 1963 as the second oral contraceptive to be introduced.  In 1988, Enovid, along with other oral contraceptives containing high doses of estrogen, was discontinued.  
As for how to take Mastoral in combination with other anabolic and androgenic steroids, the most popular regimens are methyldrostanone with Testosterone, Boldenone and Nandrolone. Before the beginning of the course, it is better to consult a sports doctor or at least an experienced athlete who has experience of using this steroid. Methyl-drostano underground anabolics by william llewellyn l also goes well with Parabolan and Primobolan. For women, the dosages of Mastoral from Alpha Pharm vary between 2-5 milligrams daily, for 4-6 weeks. This scheme minimizes the risk of virilization and other possible negative reactions of the body. Thus, athletes must independently share the tablet in two or four parts. 10 milligrams – too much dosage even for women professionals.
Athletes, like all others, may have illnesses or conditions that require them to take particular medications. If the medication an athlete is required to take to treat an illness or condition happens to fall under the prohibited list, a therapeutic use exemption may give that athlete the authorization to take the needed medicine. Criteria for granting a therapeutic use exemption are 1.) The athlete would experience significant health problems without taking the prohibited substance or method, 2.) The therapeutic use of the substance would not produce significant enhancement of performance, and 3.) There is no reasonable therapeutic alternative to the use of the otherwise prohibited substance or method. Note hormone replacement therapy (HRT), . supplementing with prescribed testosterone in any form to raise testosterone levels due to natural decreases that occur with aging (even if to just elevate levels to within ‘normal’ ranges), is NOT considered a medicinal exception. Persons using HRT would not be eligible for WPA/NANBF/IPE competition.